Ref No. 05/17.1.4/2
- Tulathromycin is a semi-synthetic macrolide antimicrobial agent, which originates from a fermentation product. It differs from many other macrolides in that it has a long duration of action that is, in part, due to its three amine groups; therefore it has been given the chemical subclass designation of triamilide.
- Macrolides inhibit essential protein biosynthesis by virtue of their selective binding to bacterial ribosomal RNA. They act by stimulating the dissociation of peptidyl-tRNA from the ribosome during the translocation process.
- Tulathromycin prossesses in vitro activity against Mannheimia (Pasteurella) haemolytica, Pasteurella multocida, Histophilus somni and Mycoplasma bovis in cattle, and Actinobacillus pleuropneumoniae, Pasteurella multocida and Mycoplasma hyopneumoniae in swine, the bacterial pathogens most commonly associated with bovine and swine respiratory disease, respectively.